Product Description of N-Methylhomopiperazine CAS#4318-37-0
N-Methylhomopiperazine, alternatively named 1-methyl-1,4-diazepane, is a seven-membered cyclic diamine compound with molecular formula C₆H₁₄N₂ and molecular weight of 114.19. At room temperature, it is a colorless to light-yellow transparent liquid.
This nitrogen-heterocyclic substance is miscible with water and polar organic solvents. It has moderate chemical reactivity on its two amine sites and needs sealed storage to prevent moisture absorption. It serves as a key synthetic intermediate for developing antihistamine, cardiovascular and antihypertensive pharmaceutical molecules.
N-Methylhomopiperazine Chemical Properties
| Boiling point | 74-75 °C/35 mmHg (lit.) |
| Density | 0.918 g/mL at 25 °C (lit.) |
| Refractive index | n20/D 1.477(lit.) |
| Fp | 113 °F |
| Form | Liquid |
| Color | Colorless to light-yellow |
| Storage temp. | -20°C |
| pka | 10.82±0.20(Predicted) |
| InChI | InChI=1S/C6H14N2/c1-8-5-2-3-7-4-6-8/h7H,2-6H2,1H3 |
| InChIKey | FXHRAKUEZPSMLJ-UHFFFAOYSA-N |
| SMILES | N1(C)CCCNCC1 |
| CAS DataBase Reference | 4318-37-0(CAS DataBase Reference) |
| NIST Chemistry Reference | N-methyl homopiperazine(4318-37-0) |
| Hazard Codes | C |
| Risk Statements | 10-22-34 |
| Safety Statements | 16-26-27-36/37/39-45 |
| RIDADR | UN 2920 8/PG 2 |
| WGK Germany | 3 |
| HazardClass | 4.1 |
| PackingGroup | II |
| HS Code | 29339900 |
Product Application of N-Methylhomopiperazine CAS#4318-37-0
N-Methylhomopiperazine is a valuable seven-membered nitrogen-heterocyclic intermediate for pharmaceutical organic synthesis. Its unique cyclic diamine structure provides good reaction activity for constructing various drug molecular skeletons.
It is mainly used for the research and production of antihistamine agents, cardiovascular and antihypertensive medicines. The active amine groups can carry out alkylation, acylation and other modification reactions, which helps to build diverse bioactive derivatives. Apart from drug manufacturing, this compound also has certain application prospects in fine-chemical synthesis.
