Product Description of Isonicotinic Acid CAS#55-22-1
Isonicotinic acid, also named pyridine-4-carboxylic acid, exists as white to off-white crystalline powder and is capable of sublimation. It has a molecular weight of 123.11 and a melting point of 319 °C.
This heterocyclic carboxylic acid is slightly soluble in cold water and ether, freely soluble in hot water, and practically insoluble in benzene. It features amphoteric chemical properties and can dissolve in both acidic and alkaline aqueous solutions. Benefiting from favorable thermal and oxidation-resistant stability, the molecule provides reliable reaction activity for derivatization.
Isonicotinic Acid Chemical Properties
| Melting point | ≥300 °C (lit.) |
| Boiling point | 260 °C (15 mmHg) |
| density | 1,47g/cm |
| refractive index | 1.5423 (estimate) |
| Fp | 260°C/15mm |
| storage temp. | no restrictions. |
| solubility | 6g/l |
| pka | 4.96(at 25℃) |
| form | Needle-shaped crystals /crystalline powder |
| color | White to off-white |
| PH | 3-4 (6g/l, H2O, 20℃)(saturated solution) |
| Water Solubility | 5.2 g/L (20 ºC) |
| Merck | 145187 |
| BRN | 109599 |
| InChIKey | TWBYWOBDOCUKOW-UHFFFAOYSA-N |
| CAS DataBase Reference | 55-22-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Isonicotinic acid(55-22-1) |
| EPA Substance Registry System | Isonicotinic acid (55-22-1) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | NS1103000 |
| TSCA | Yes |
| HS Code | 29333999 |
| Toxicity | LD50 orally in Rabbit: 5000 mg/kg |
Product Application of Isonicotinic Acid CAS#55-22-1
Isonicotinic acid functions as a multi-purpose chemical intermediate with broad-ranging industrial uses across multiple sectors. Its most significant use is acting as an essential starting material to manufacture isoniazid (isonicotinic acid hydrazide), one of the first-line anti-tuberculosis medications, alongside a series of other pharmaceutical molecules.
Apart from drug-making workflows, this substance can also be deployed as a corrosion inhibitor, electroplating processing additive, stabilizer for photosensitive resin, heat stabilizer for polyvinyl chloride (PVC), and flotation reagent for non-ferrous metals.
In analytical chemistry, it serves as an analytical reagent and pH adjustment agent. Its reactive carboxyl group enables convenient derivatization reactions to build various bioactive heterocyclic structures for drug discovery.
