Product Description of 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone CAS#86404-63-9
2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone, commonly referred to as DFTA, is an important fluorine-containing heterocyclic intermediate with molecular formula C10H6F2N3O. It is a white to pale yellow crystalline solid. This product shows low solubility in water and dissolves well in conventional organic solvents like dichloromethane and ethanol.
The compound owns active carbonyl and triazole groups, enabling it to participate in various condensation reactions. It is mainly applied for synthesizing triazole fungicides and pharmaceutical molecules.
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone Chemical Properties
| Melting point | 103-107 °C(lit.) |
| Boiling point | 388.0±52.0 °C(Predicted) |
| density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 2.05±0.10(Predicted) |
| color | White to pale yellow |
| CAS DataBase Reference | 86404-63-9(CAS DataBase Reference) |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29339900 |
Product Application of 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone CAS#86404-63-9
This compound is a vital fine-chemical intermediate within the pharmaceutical sector. It is primarily utilized for constructing the molecular framework of voriconazole and other triazole-class antifungal agents, supporting the multi-step production of corresponding active pharmaceutical ingredients.
Apart from drug synthesis, it can be employed as a laboratory synthetic reagent in biochemical and life-science research. It participates in building diversified complex heterocyclic molecules for compound screening and related exploratory chemical studies.
