Products Description of 1-(2,6-Dichlorophenyl)indolin-2-one CAS#15362-40-0
1-(2,6-Dichlorophenyl)indolin-2-one, also known as N-(2,6-dichlorophenyl)-2-indolinone or diclofenac amide, is an indolinone derivative with a molecular formula of C14H9Cl2NO and a molecular weight of 278.13. It is supplied as a off-white to light brown crystalline powder with high purity of 99.0% minimum, and is soluble in common organic solvents such as ethanol, ethyl acetate, dichloromethane and DMF, while being sparingly soluble in water.
As a well defined aromatic heterocyclic compound, it features a 2-oxindole core substituted with a 2,6-dichlorophenyl group, which endows it with valuable structural characteristics for medicinal chemistry.
1-(2,6-Dichlorophenyl)indolin-2-one Chemical Properties
| Melting point | 115-119°C |
| Boiling point | 488.6±45.0 °C(Predicted) |
| density | 1.432±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | -4.85±0.20(Predicted) |
| Form | Crystalline powder or solid |
| Color | Off-White to Light Brown |
| BRN | 1538309 |
| Stability: | Stability |
| CAS DataBase Reference | 15362-40-0(CAS DataBase Reference) |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | NM3259200 |
| HS Code | 29337900 |
| Toxicity | mouse,LD50,unreported,1200mg/kg (1200mg/kg),Pharmaceutical Chemistry Journal Vol. 21, Pg. 275, 1987. |
Product Application of 1-(2,6-Dichlorophenyl)indolin-2-one CAS#15362-40-0
1-(2,6-Dichlorophenyl)indolin-2-one plays an important role in the pharmaceutical industry as a key intermediate in the synthesis of diclofenac and related nonsteroidal anti-inflammatory drugs. The 2-oxindole ring with the 2,6-dichlorophenyl substituent provides a structurally well defined scaffold that can be further transformed through hydrolysis, acylation and other reactions to construct the active pharmaceutical ingredient.
In addition, the compound is widely used as a pharmaceutical reference standard and impurity marker, including its designation as diclofenac related compound A in the USP, supporting quality control, analytical method development and stability studies in drug manufacturing. It is also employed in medicinal chemistry research for the preparation of structurally related analogs and in fine chemical synthesis.
