Products Description of 2-Chlorophenol CAS#95-57-8
2-Chlorophenol (CAS#95-57-8) is an aromatic chlorinated phenolic compound. It appears as a colorless to light-amber oily liquid with a characteristic phenolic odor. Its melting point is 8 ℃ and boiling point is 175-176 ℃. It is slightly soluble in water and miscible with ethanol, ether and other organic solvents.
This chemical serves as an important synthetic intermediate in organic chemistry. It is widely used for manufacturing pesticides, pharmaceuticals, dyes and preservatives.
2-Chlorophenol Chemical Properties
| Melting point | 8 °C (lit.) |
| Boiling point | 175-176 °C (lit.) |
| density | 1.241 g/mL at 25 °C (lit.) |
| vapor pressure | 13.3 hPa (50 °C) |
| refractive index | n20/D 1.558(lit.) |
| Fp | 147 °F |
| storage temp. | under inert gas (Argon) |
| solubility | alcohol: freely soluble |
| pka | 8.49(at 25℃) |
| form | Oily liquid |
| color | Colorless to light-amber |
| Water Solubility | 28.5 g/L (20 ºC) |
| Merck | 142154 |
| BRN | 1905114 |
| Henry's Law Constant | 6.44 x 10-6 atm?m3/mol at 20 °C (Sheikheldin et al., 2001) |
| Dielectric constant | 8.2（19℃） |
| Stability: | Stable. Hygroscopic. Combustible. Incompatible with oxidizing agents, acid anhydrides, acid chlorides. |
| InChIKey | ISPYQTSUDJAMAB-UHFFFAOYSA-N |
| LogP | 2.18 at 20℃ |
| CAS DataBase Reference | 95-57-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Chlorophenol(95-57-8) |
| EPA Substance Registry System | o-Chlorophenol (95-57-8) |
| Hazard Codes | Xn,N,T,F |
| Risk Statements | 20/21/22-51/53-39/23/24/25-23/24/25-11 |
| Safety Statements | 28-61-28A-45-36/37-16-7 |
| RIDADR | UN 2021 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | SK2625000 |
| F | 9 |
| Autoignition Temperature | 550 °C |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29081000 |
| Hazardous Substances Data | 95-57-8(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 0.67 g/kg (Deichmann) |
Product Application of 2-Chlorophenol CAS#95-57-8
2-Chlorophenol is a versatile fine chemical intermediate widely applied in pesticide, pharmaceutical, dye and plastic industries. It can also be used as an alcohol denaturant and a selective solvent for refined mineral oil, with additional applications in microscopic analysis and plant growth regulation.
In the dye industry, it acts as a key synthetic intermediate. It undergoes nitration reaction with dilute nitric acid to generate mono-nitro and di-nitro derivatives, which are further processed to manufacture multiple dye products, including Neutral Brilliant Green BL.
In pesticide manufacturing, 2-chlorophenol serves as a core raw material for synthesizing triadimefon, cypermethrin, propanil and chlorfenapyr. It is also used in the production of wool fungicides, anti-drop agents and multi-functional plant growth regulators, as well as various insecticides, acaricides and mite ovicides.
For pharmaceutical synthesis, this compound is utilized to prepare a series of medical intermediates and finished products, including sodium 5-chloro-2-hydroxybenzoate, clofibrate and p-chlorophenoxyisobutyric acid.
