Products Description of 4,4'-Diaminodiphenylsulfone CAS#80-08-0
4,4'-Diaminodiphenyl sulfone also known as Dapsone or DDS, is a significant aromatic sulfone compound manufactured via high-temperature and high-pressure amination reaction. This industrial-grade material is mainly adopted for synthesizing polysulfoneamide resins and other polymer materials, together with diverse acid azo dyes and disperse dyes.Moreover, it can act as a curing agent for epoxy resins and finds applications in electrical insulation materials and textile machinery. It also serves as a catalyst for certain chemical reactions.
Within the pharmaceutical industry, this pharma-grade material complies with pharmacopoeia specifications with controlled heavy metal and impurity levels. It inhibits bacterial folic acid synthesis and possesses antibacterial and anti-inflammatory properties. As a core API, it is widely used to manufacture oral and topical pharmaceutical formulations.
4,4'-Diaminodiphenylsulfone Chemical Properties
| Melting point | 175-177 °C(lit.) |
| Boiling point | 511.7±35.0 °C(Predicted) |
| density | 1.2701 (rough estimate) |
| vapor pressure | 0.004Pa at 25℃ |
| refractive index | 1.5950 (estimate) |
| storage temp. | 2-8°C |
| solubility | 0.38g/l |
| form | Crystalline Powder |
| pka | pKb 13.0(at 25℃) |
| color | White to beige |
| PH | 5.5-7.5 (H2O, 20℃)(saturated aqueous solution) |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Merck | 142822 |
| BRN | 788055 |
| BCS Class | 4,2 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | MQJKPEGWNLWLTK-UHFFFAOYSA-N |
| LogP | 0.97 at 25℃ |
| CAS DataBase Reference | 80-08-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Dapsone(80-08-0) |
| IARC | 3 (Vol. 24, Sup 7) 1987 |
| EPA Substance Registry System | Dapsone (80-08-0) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22 |
| RIDADR | 3249 |
| WGK Germany | 1 |
| RTECS | BY8925000 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29051620 |
| HS Code | 29309070 |
| Hazardous Substances Data | 80-08-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1000 mg/kg LD50 dermal Rabbit > 4000 mg/kg |
Product Application of 4,4'-Diaminodiphenylsulfone CAS#80-08-0
Dapsone is a sulfone antibacterial agent that displays potent activity against Mycobacterium leprae. Its preparations are extensively applied for leprosy treatment and acknowledged as first-line therapeutic drugs. Dapsone exerts pharmacological effects via inhibiting bacterial dihydrofolate synthase (DHPs). This action hinders folic acid biosynthesis and interferes with bacterial protein synthesis.
Apart from antibacterial performance, dapsone possesses remarkable anti-inflammatory properties. It efficiently eliminates toxic oxygen free radicals produced upon neutrophil stimulation and suppresses neutrophil aggregation and activation. As a result, the release of inflammatory mediators is restrained, and subsequent tissue injury is alleviated.
Clinical research reveals that an oral administration of 100 mg dapsone yields blood drug concentrations 500–600 times the minimum inhibitory concentration for Mycobacterium leprae. Recent investigations have verified its efficacy against other infectious conditions, inflammatory dermatoses, autoimmune bullous diseases, urticaria and other illnesses, illustrating its extensive therapeutic prospects.
