Products Description of Clavulanic Acid CAS#58001-44-8
Clavulanic acid is a naturally occurring beta-lactamase inhibitor produced by the microorganism Streptomyces clavuligerus, with a molecular formula of C8H9NO5 and a molecular weight of 199.16. It is supplied as a white to off white crystalline powder, typically in the form of its stable potassium salt for commercial pharmaceutical use.
Clavulanic acid acts by irreversibly inactivating a wide range of beta-lactamase enzymes, thereby protecting co-administered beta-lactam antibiotics from enzymatic degradation and restoring their activity against resistant bacterial strains.
Clavulanic Acid Chemical Properties
| Boiling point | 545.8±50.0 °C(Predicted) |
| density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light, stored under nitrogen |
| solubility | H2O : 50 mg/mL (251.05 mM; Need ultrasonic) |
| pka | 3.68±0.20(Predicted) |
| Form | Crystalline powder |
| Color | White to off white |
| Solubility | Freely soluble in water and methanol; sparingly soluble in ethanol; practically insoluble in non-polar solvents |
| Stability | Moisture and heat sensitive; susceptible to degradation |
| Storage Condition | Store at 2-8°C in tightly sealed, light resistant containers, protected from moisture |
Product Application of Clavulanic Acid CAS#58001-44-8
Clavulanic-acid acts as a beta-lactamase suppressing agent. Its standalone germ-killing capacity remains relatively mild, yet it can efficiently block beta-lactamase secreted by staphylococcus strains and the majority of gram-negative microbes.
This ingredient creates irreversible binding complexes with beta-lactamase and deactivates the target enzyme. Mixed together with beta-lactam antibacterial agents, it shields medicines from enzyme-triggered breakdown, strengthens bactericidal potency, extends the antimicrobial range and tackles drug-resistant bacteria.
For real-world medical usage, it is frequently compounded with other antibiotics. Its mixture with amoxicillin is marketed as Augmentin, and the ticarcillin-matched preparation goes under the brand-name Timentin.
